Sleep apnea indicates shift to ketogenic substrate oxidation. You want to be in ketosis to deplete deuterium. Breathing exercises to switch metabolism to peroxisomes, in order to deplete deuterium \r
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Cameron Borg: \"Can you elaborate just briefly on what you meant by oxygen pressure? Perhaps you meant that that's some sort of compensatory mechanism here.\" \r
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László Boros, MD: \"Yeah, the partial pressure of oxygen comes from O₂ that is dissolved in your body. So mitochondria is supplied by oxygen that comes through the hemoglobin that is dropped in the tissues. But there's also some oxygen that is dissolved in your blood. It's O₂ and your peroxisomes can use that directly. That's why when you sleep, you have these sleep apnea simply because you want to shift to a ketogenic substrate oxidation in the middle of the night. You you want to be in ketosis by the morning time when you wake up. So your breathing slows down. You stop oxidizing. You want to deplete deuterium throughout the night for the morning hours when you wake up. You want to be in a ketosis state. \r
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\"So you burn up your glucose very fast after you fall asleep. You have these rapid eye movements, these muscle and tissue activities. And from 02:00 – 03:00 at night, you start oxidizing fat. And O₂, the dissolved oxygen through peroxisomal β-oxidation, is the source of oxygen and hydrogen peroxide that is surely low in deuterium, because peroxisomes can only use fat and remodel fat and produce hydrogen peroxide from fat sources which are low in deuterium. And that can be kind of switched to the mitochondrial matrix or transferred to the mitochondrial matrix for catalase to make metabolic water from it. \r
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\"So by oxygen pressure and by elevation changes oxygen pressure, meaning that if you live at higher altitudes then your body will adapt to to a lower dissolved oxygen pressure, then you start producing certain hormones that would increase for daytime activities, that would increase your red blood cell count to deliver more oxygen for mitochondria, to be able to produce the same amount of metabolic water, and thus energy. So in fact, when you live close to the kind of the ocean water level, then you're going to have a different oxygen pressure, oxygen tension, partial pressure in your circulation. And even a few hundred meters, that's why air always flows up in chimneys, even a few meters, a few hundred meters can change the biological settings of peroxisome or mitochondrial cross talk. And peroxisome produce low-deuterium hydrogen peroxide that you can recycle in your mitochondria. \r
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\"It's a very interconnected system. We wrote about this phenomenon in the paper that we wrote about this Himalaya climbing experience, and sure enough, we believe that by kind of retaining certain breathing practices, and there are Wim Hof, there are Buyteko, and there are some other breathing practices. Those are actually changing these oxygen pressure partial pressures and switch metabolism from mitochondrial to peroxisomes, and those can only utilize fatty acids or ketones, and for that you deplete deuterium through the system constantly.\" \r
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László Boros, MD with Cameron Borg @ 01:04:18–01:08:01 (posted 2025-09-23) https://youtu.be/DmuO5uFuAcE&t=3858